Small, nonfunctional, asymptomatic, well-differentiated islet cell tumors potentially
can be observed in the appropriate clinical setting.
Keywords
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References
- One hundred years after "carcinoid": epidemiology of and prognostic factors for neuroendocrine tumors in 35,825 cases in the United States.J Clin Oncol. 2008; 26: 3063-3072
- Non-functional neuroendocrine carcinoma of the pancreas: incidence, tumor biology, and outcomes in 2,158 patients.J Gastrointest Surg. 2010; 14: 541-548
- A nationwide population-based study on the survival of patients with pancreatic neuroendocrine tumors in the Netherlands.World J Surg. 2018; 42: 490-497
- Cytological differentiation of asymptomatic pancreatic islet cell tumours in autopsy material.Virchows Arch A Pathol Anat Histol. 1975; 365: 275-288
- Clinical pathology of endocrine tumors of the pancreas. Analysis of autopsy cases.Dig Dis Sci. 1991; 36: 933-942
- The epidemiology of gastroenteropancreatic neuroendocrine tumors.Endocrinol Metab Clin North Am. 2011; 40 (vii): 1-18
- Current trends of the incidence and pathological diagnosis of gastroenteropancreatic neuroendocrine tumors (GEP-NETs) in Korea 2000-2009: multicenter study.Cancer Res Treat. 2012; 44: 157-165
- Clinically detected gastroenteropancreatic neuroendocrine tumors are on the rise: epidemiological changes in Germany.World J Gastroenterol. 2013; 19: 9012-9019
- Epidemiological trends of pancreatic and gastrointestinal neuroendocrine tumors in Japan: a nationwide survey analysis.J Gastroenterol. 2015; 50: 58-64
- Population-level analysis of pancreatic neuroendocrine tumors 2 cm or less in size.Ann Surg Oncol. 2013; 20: 2815-2821
- Impact of extent of surgery on survival in patients with small nonfunctional pancreatic neuroendocrine tumors in the United States.Ann Surg Oncol. 2014; 21: 3515-3521
- Observation versus resection for small asymptomatic pancreatic neuroendocrine tumors: a matched case-control study.Ann Surg Oncol. 2016; 23: 1361-1370
- Endocrine tumours of the gastrointestinal tract.in: Solcia EKp G. Sobin L.H. Histologic typing of endocrine tumours, WHO international histological classification of tumours. Springer, New York2000: 57-67
- Management of neuroendocrine carcinomas of the pancreas (WHO G3): A tailored approach between proliferation and morphology.World J Gastroenterol. 2016; 22: 9944-9953
- WHO classification of tumours of endocrine organs. vol. 10. IARC Press, Lyon (France)2017 4th editon.
- Neuroendocrine tumors, version 1.2015.J Natl Compr Canc Netw. 2015; 13: 78-108
- ENETS consensus guidelines update for the management of patients with functional pancreatic neuroendocrine tumors and non-functional pancreatic neuroendocrine tumors.Neuroendocrinology. 2016; 103: 153-171
- Small, nonfunctioning, asymptomatic pancreatic neuroendocrine tumors (PNETs): role for nonoperative management.Surgery. 2012; 152: 965-974
- Nonfunctional pancreatic neuroendocrine tumors <2 cm on preoperative imaging are associated with a low incidence of nodal metastasis and an excellent overall survival.J Gastrointest Surg. 2013; 17: 2105-2113
- Observational study of natural history of small sporadic nonfunctioning pancreatic neuroendocrine tumors.J Clin Endocrinol Metab. 2013; 98: 4784-4789
- Surgery versus surveillance for well-differentiated, nonfunctional pancreatic neuroendocrine tumors: an 11-year analysis of the national cancer database.Oncologist. 2020; 25: e276-e283
- Comparison of surgical results in patients with advanced and limited disease with multiple endocrine neoplasia type 1 and Zollinger-Ellison syndrome.Ann Surg. 2001; 234 ([discussion: 505–6]): 495-505
- Impact of tumor size and nodal status on recurrence of nonfunctional pancreatic neuroendocrine tumors ≤2 cm after curative resection: A multi-institutional study of 392 cases.J Surg Oncol. 2019; 120: 1071-1079
- The conundrum of < 2-cm pancreatic neuroendocrine tumors: A preoperative risk score to predict lymph node metastases and guide surgical management.Surgery. 2019; 166: 15-21
- Pancreatic neuroendocrine tumors: radiographic calcifications correlate with grade and metastasis.Ann Surg Oncol. 2012; 19: 2295-2303
- Predicting aggressive behavior in nonfunctioning pancreatic neuroendocrine tumors.Surgery. 2013; 154 ([discussion: 791–3]): 785-791
- Surgical resection provides an overall survival benefit for patients with small pancreatic neuroendocrine tumors.J Gastrointest Surg. 2015; 19 ([discussion: 123]): 117-123
- EUS-FNA predicts 5-year survival in pancreatic endocrine tumors.Gastrointest Endosc. 2009; 70: 907-914
- Fine-needle aspiration-based grading of pancreatic neuroendocrine neoplasms using Ki-67: Is Accurate WHO grading possible on cytologic material?.J Am Soc Cytopathol. 2018; 7: 154-459
- Pancreatic neuroendocrine tumours: the role of endoscopic ultrasound biopsy in diagnosis and grading based on the WHO 2017 classification.Dig Dis. 2019; 37: 325-333
- Pancreatic neuroendocrine tumours: hypoenhancement on arterial phase computed tomography predicts biological aggressiveness.HPB (Oxford). 2014; 16: 304-311
- Neuroendocrine tumors of the pancreas: Degree of cystic component predicts prognosis.Surgery. 2016; 160: 708-713
- Cystic pancreatic neuroendocrine tumors: a clinicopathologic study.Am J Surg Pathol. 2012; 36: 1666-1673
- Operative versus nonoperative management of nonfunctioning pancreatic neuroendocrine tumors.J Gastrointest Surg. 2016; 20: 277-283
- A survival analysis of patients with localized, asymptomatic pancreatic neuroendocrine tumors: no surgical survival benefit when examining appropriately selected outcomes.J Gastrointest Surg. 2019; https://doi.org/10.1007/s11605-019-04433-4
- Small pancreatic and periampullary neuroendocrine tumors: resect or enucleate?.J Gastrointest Surg. 2009; 13: 1692-1698
- Implications of incidentally discovered, nonfunctioning pancreatic endocrine tumors: short-term and long-term patient outcomes.Arch Surg. 2011; 146: 534-538
Article info
Publication history
Published online: June 17, 2020
Footnotes
The authors have no commercial interests to disclose.
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© 2020 Elsevier Inc. All rights reserved.