The first published report of a successful pancreaticoduodenectomy was published by Allen O. Whipple in 1935 [
]. Whipple reported 3 patients who underwent a 2-stage procedure with pancreatic duct ligation: one patient died in the perioperative period; another died 8 months later from cholangitis, and the last from metastases after 28 months. This initial report was followed by a series describing a single-stage procedure [
- Whipple A.O.
- Parsons W.B.
- Mullins C.R.
Treatment of carcinoma of the ampulla of Vater.
Ann Surg. 1935; 102: 763-779
], the fundamentals of which we recognize today as the Whipple procedure. These fundamentals included (1) resection and reconstruction in one stage; (2) avoidance of cholecystoenterostomy by implantation of the bile duct into the jejunum, and (3) implantation of the pancreatic duct into the jejunum. Following the modification of pylorus preservation by Traverso and Longmire [
- Whipple A.O.
Pancreaticoduodenectomy for islet carcinoma: a five-year follow-up.
Ann Surg. 1945; 121: 847-852
], the technical aspects of pancreaticoduodenectomy have remained essentially unchanged since Whipple described the procedure in 1935.
- Traverso L.W.
- Longmire Jr., W.P.
Preservation of the pylorus in pancreaticoduodenectomy.
Surg Gynecol Obstet. 1978; 146: 959-962
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- Treatment of carcinoma of the ampulla of Vater.Ann Surg. 1935; 102: 763-779
- Pancreaticoduodenectomy for islet carcinoma: a five-year follow-up.Ann Surg. 1945; 121: 847-852
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© 2011 Elsevier Inc. Published by Elsevier Inc. All rights reserved.