Hereditary nonpolyposis colorectal cancer (HNPCC), often called Lynch syndrome, may
be described as a hereditary predisposition to developing colorectal and extracolonic
cancers. Accounting for approximately 3% of all colorectal malignancies, it is the
most common cause of hereditary colorectal cancer [
[1]
]. The diagnosis is based on clinical criteria related to family history of certain
HNPCC-defining cancers, such as those of the colorectum, uterus, stomach, ovaries,
urinary epithelium, and small bowel. The syndrome is characterized by early onset
of cancer, and an elevated clinical suspicion is needed to make a timely diagnosis
so that appropriate surveillance and intervention can be performed to decrease deaths
from cancer. This review provides a brief background on HNPCC and reviews the surgical
management of the disease.To read this article in full you will need to make a payment
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Publication history
Published online: July 04, 2011
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© 2011 Published by Elsevier Inc.
