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Review Article| Volume 45, ISSUE 1, P249-263, September 2011

Perioperative Normothermia During Major Surgery: Is It Important?

      Perioperative hypothermia (PH), usually defined as a temperature of less than 36.0°C during the perioperative period, can result from anesthesia-induced thermoregulatory inhibition combined with exposure to a cold operating room environment and is estimated to occur in 50% to 70% of patients undergoing anesthesia and major surgery [
      • Forstot R.M.
      The etiology and management of inadvertent perioperative hypothermia.
      ]. Almost all anesthetics, including opioids, propofol, inhalational agents, and spinal/epidural anesthetics, have been shown to impair thermoregulatory mechanisms through their effects on the brain/hypothalamus, impairment of peripheral vasoconstriction, and the shivering response. As a result, patients (particularly the very young and the elderly) exposed to these agents become poikilothermic and body temperature decreases to less than 36.0°C in a cool operating room environment [
      • Frank S.M.
      • Beattie C.
      • Christopherson R.
      • et al.
      Epidural versus general anesthesia, ambient operating room temperature, and patient age as predictors of inadvertent hypothermia.
      ]. Return to normothermia often requires several hours, which in turn increases exposure to PH (and its attendant morbidities) beyond the immediate intraoperative period.
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