The potential use of stem cells as therapy for failing organ systems is being explored
in diverse organ and tissue injury areas. It has been shown that bone marrow-derived
stem cells can transdifferentiate into a variety of adult cell types, including hepatocytes
[
1
,
2
,
3
,
4
,
5
]. Applications for hematopoietic stem cells and cytokines aimed at mobilizing stem
cells in other organs have been assessed with benefit shown in myocardial ischemia
[
6
,
7
] and acute kidney injury [
- Achilli F.
- Malafronte C.
- Lenatti L.
- et al.
Granulocyte colony-stimulating factor attenuates left ventricular remodeling after
acute anterior STEMI: results of the single-blind, randomized, placebo-controlled
multicentre STem cEll Mobilization in Acute Myocardial Infarction (STEM-AMI) Trial.
Eur J Heart Fail. 2010; 12: 1111-1121
[8]
]. The aim of this review is to assess the emerging evidence for the role of stem cells
in assisting the acutely failing liver.To read this article in full you will need to make a payment
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Article info
Publication history
Published online: July 13, 2011
Footnotes
Dr Cameron is a recipient of the American Surgical Association Foundation Fellowship Award as well as an extramural research grant from the Genzyme Corporation in Cambridge, Massachusetts.
Identification
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© 2011 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
